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Michael R. Rosen, M.D.
Pfeiffer Professor of Pharmacology and Pediatrics; Director, Center for Molecular Therapeutics
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Research
Summary
Developmental biology of the heart; cardiac-autonomic interactions; Mechanisms for cardiac arrhythmias and their prevention and control
We study the developmental changes that occur in the mechanisms that control cardiac rhythm. The heart shows important changes in its normal physiology with growth and development that influence the normal heartbeat and the response of the individual to the interposition of cardiac disease. We perform research on animal models ranging in age from the fetus through the adult with a view towards understanding the changes in electrophysiologic properties and ionic fluxes that control the normal heartbeat, as well as the mechanisms responsible for developmental changes in the cardioactive agents.
We study the interaction of the heart with elements of the nervous system. We are concerned with the development of specific membrane receptors and their associated proteins that transmit signals from various neurohumors to the cell interior. Here, we consider both mechanisms of neurohumor action on the heart and nerve cells, as well as the links between the biochemical and electrophysiologic control mechanism. The importance of these studies is based on the central role of the autonomic nervous system in modulating the normal heartbeat, the response to stress, and the occurrence of certain lethal cardiac arrhythmias.
In our studies of cardiac arrhythmias and their prevention and treatment we are interested in the events that govern the initiation of the heartbeat in various pathological settings. There are two areas of primary emphasis: one is atrial fibrillation, an arrhythmia that afflicts 5% of the population over age 65 and is a major cause of morbidity and death via stroke. The second is the property of cardiac memory, which can be induced by pacing the heart electrically, and can be modulated a way that either suppresses or facilitates the occurrence of arrhythmias. The central goal of our work is to develop means for the identification, prevention and treatment of arrhythmias that will be readily applicable to the patient.
http://www.cumc.columbia.edu/dept/cmt/participants/bios/rosen.shtml
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Selected Publications:
1. Plotnikov AN, Yu H, Geller C, Gainullin RZ, Chandra P, Patberg KW, Friezema S, Danilo P Jr, Cohen IS, Feinmark SJ, Rosen MR (2003) Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart Circulation
107:2844-2849
2. 2. Qu J, Plotnikov AN, Danilo P Jr, Shlapakova I, Cohen IS, Robinson RB, Rosen MR (2003) Expression and function of a biological pacemaker in canine heart Circulation
107:1106-1109
3. Rosen MR (2002) The electrocardiogram 100 years later: Electrical insights into molecular messages Circulation
106:2173-2179
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